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Hydroxychloroquine Sulfate is a prescription anti-malarial medication. It is used for the treatment of malaria, a condition that is carried by mosquitos. It is also used for rheumatoid arthritis, a progressive disease that causes irritation in the joint. This condition causes deformity in the feet, legs, and ankles. It is also prescribed to treat lupus, a condition where the immune system acts against its healthy cells.